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There is no "Motaba virus" in Highschool of the Dead. The cause of the Outbreak is known as the Killer's Disease or Murder Syndrome. The origin or first case of the disease is unknown, but characters speculate that it may have been an experimental biological weapon of the U.S. or Japanese military. All we know is that governments and military around the world acted within hours of the initial global Outbreak with a focus on containing those infected and gathering survivors rather than destroying the disease itself.

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